Preheat oven to 350 degrees. Grease a large cast iron pan.
In a large bowl, stir together cream cheese, ricotta cheese, 2 cups of mozzarella cheese, Parmesan cheese and 1 1/2 teaspoons Italian seasoning.
Pile cheese mixture in the center of the cast iron pan.
Cut each biscuit in half and roll each piece into a ball. Arrange them in a circle around the cheese.
Pour pizza sauce on top of cheese mound. Scatter half the pepperoni on top. Sprinkle the remaining mozzarella cheese on top of pepperoni and then arrange the rest of the pepperoni on top of the cheese.
In a small bowl, stir together oil, garlic, Italian seasoning, and red pepper flakes. Brush on top of biscuits.
Bake for 45 minutes. Cover with aluminum foil after 30 minutes if getting too brown.