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+ servings

Cheesy Chipotle Meatloaf

Cheesy Chipotle Meatloaf has lots of bold flavor. Caramelized onions are mixed into the meatloaf and there's a smoky sweet glaze covered with cheese. This is not your ordinary meatloaf.
Course Dinner, Main Dish
Cuisine Southwestern
Keyword chipotle, ground beef, meatloaf
Prep Time 20 minutes
Cook Time 1 hour 10 minutes
Servings 8
Calories 402kcal


  • 2 teaspoons Vegetable oil
  • 2 teaspoons butter
  • 2 cups chopped yellow onion
  • salt and pepper
  • 2/3 cup Panko crumbs
  • 1/3 cup milk
  • 1 pound ground beef (85 to 90% lean)
  • 1/2 pound ground pork
  • 2 large eggs, lightly beaten
  • 1 1/2 teaspoons salt
  • 1/2 teaspoon pepper
  • 1/2 teaspoon dried oregano
  • 1/2 cup cubed cheddar cheese
  • 1/2 cup cubed Pepper Jack cheese
  • 1/3 cup ketchup
  • 1 tablespoon packed light brown sugar
  • 1 tablespoon Worcestershire sauce
  • 2 tablespoons finely minced chipotle peppers in adobo sauce
  • 1/2 cup shredded cheddar cheese
  • 1/2 cup shredded Pepper jack cheese


  • Preheat oven to 350 degrees.
  • Heat oil and butter in a large nonstick skillet. Add onion and cook over medium heat for 10 to 15 minutes, stirring frequently. Season with salt and pepper. Let cool.
    Note: Turn heat down if onions look like they might start to burn.
  • Add Panko crumbs to a large bowl and drizzle milk over them. Let sit a few minutes.
  • Add ground beef, ground pork, eggs, salt, pepper, and oregano. Stir until evenly mixed.
    Stir in cubed cheddar and pepper jack.
  • In a small bowl stir together ketchup, brown sugar, Worcestershire sauce, and chipotle peppers. Add 2 tablespoons to the ground beef mixture and mix in. Reserve the remaining mixture for the topping.
  • Gently press meatloaf mixture into a 9x5-inch pan.
    Bake for 65 minutes and then carefully pour any grease out of the pan, being sure not to tip the pan too much.
  • Spread the remaining ktechup mixture on top of the meatloaf and sprinkle the shredded cheese on top.
  • Return to oven for 5 minutes to melt the cheese.
  • Let cool 15 minutes before slicing.


Calories: 402kcal