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+ servings

Chicken Broccoli & Ziti Casserole

Chicken Broccoli & Ziti Casserole has a delicious white cream sauce, lots of asiago cheese, and buttery bread crumbs. This from-scratch casserole makes a filling dinner the whole family will enjoy.
Course Dinner, Main Dish
Cuisine American
Keyword Casserole, chicken, pasta
Prep Time 30 minutes
Cook Time 25 minutes
Servings 8


  • 4 slices hearty white sandwich bread, torn into pieces
  • 6 garlic cloves, minced
  • 2 1/2 cups shredded Asiago cheese, divided
  • 2 tablespoons melted butter
  • 12 ounces ziti
  • 5 tablespoons butter
  • 1 medium onion, diced
  • 1/2 teaspoon crushed red pepper flakes
  • 1/4 cup all-purpose flour
  • 1/3 cup white wine
  • 3 cups whole milk
  • 2 cups chicken broth
  • 3 to 4 boneless, skinless chicken breasts, cut into bite-sized pieces
  • 1/2 teaspoon black pepper
  • 5 cups broccoli florets


  • Place bread, half the garlic, 1/2 cup of shredded Asiago cheese, and melted butter in a food processor. Pulse until bread is turned into crumbs. Set aside.
  • Bring a large pot of water to a boil. Add 1 tablespoon of salt and the ziti. Cook according to package directions. Drain. Set aside.
  • Preheat oven to 375 degrees and grease a 9x13-inch baking dish.
  • To the same pot that you cooked the pasta in, add the 5 tablespoons of butter. Add onion and cook for 5 minutes. Add the remaining garlic and red pepper flakes and cook 1 minute.
  • Stir in the flour and cook 1 minute.
    Whisk in the wine.
  • Gradually whisk in the milk and the chicken broth. Bring to a boil.
  • Add chicken and simmer for 5 minutes. Remove from heat and stir in remaining 2 cups of shredded Asiago cheese and black pepper. Check for seasoning and add salt to taste.
  • Place broccoli in a microwave-safe bowl with 1 tablespoon of water. Cover with plastic wrap and microwave for 2 to 3 minutes.
  • Add ziti and broccoli to the pot with the sauce and stir to mix. Transfer mixture to prepared baking dish.
    Scatter the bread crumb mixture on top.
  • Bake for 20 to 25 minutes. If bread crumbs start getting too browned, cover loosely with foil.