Stir together first 7 ingredients in a medium bowl. Add brisket pieces and toss to coat well.
Heat oil in a large cast iron or nonstick pan over medium-high heat. Add brisket. Cook in 2 batches if necessary. Sprinkle any leftover spice mixture over the brisket. Cook until browned on all sides.
Transfer brisket to a 6-quart or larger crock pot.
Add bell pepper, onion, and garlic to the pan. No need to wipe it clean. You want it to get flavored from the spices and grease left in the pan. Cook just until starting to get soft and then add to crock pot.
Add beans, diced tomatoes, beef broth, and crushed red pepper flakes to the crock pot.
Cover and cook on LOW for 8 hours or on HIGH for 6 hours. Stir in lime juice. Serve with Lime Cream.
To make lime cream, stir together all ingredeints in a small bowl.
This recipe originally appeared on spicysouthernkitchen.com